Binomial Theorem

If ${ }^n C_0,{ }^n C_1,{ }^n C_2, \ldots,{ }^n C_n$ respectively are the binomial coefficients in the expansion of $(1+x)^n$, then when $n=10, \sum_{r=1}^{10}{ }^n C_r \cdot r(r-4)=$